ES8604600A1 - Un metodo para la preparacion de derivados penem - Google Patents
Un metodo para la preparacion de derivados penemInfo
- Publication number
- ES8604600A1 ES8604600A1 ES533187A ES533187A ES8604600A1 ES 8604600 A1 ES8604600 A1 ES 8604600A1 ES 533187 A ES533187 A ES 533187A ES 533187 A ES533187 A ES 533187A ES 8604600 A1 ES8604600 A1 ES 8604600A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- define
- preparation
- penem
- penem derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002961 penems Chemical class 0.000 title 1
- -1 HYDROXY, HYDROXYL Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012039 electrophile Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/502,894 US4595539A (en) | 1983-06-10 | 1983-06-10 | Preparation of penem derivatives and azetidinone intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8604600A1 true ES8604600A1 (es) | 1986-02-01 |
| ES533187A0 ES533187A0 (es) | 1986-02-01 |
Family
ID=23999845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES533187A Expired ES8604600A1 (es) | 1983-06-10 | 1984-06-06 | Un metodo para la preparacion de derivados penem |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4595539A (en]) |
| EP (1) | EP0128725A1 (en]) |
| JP (2) | JPS6140257A (en]) |
| KR (1) | KR870001066B1 (en]) |
| AU (1) | AU544229B2 (en]) |
| DK (1) | DK281884A (en]) |
| ES (1) | ES8604600A1 (en]) |
| FI (1) | FI842329A7 (en]) |
| GR (1) | GR82109B (en]) |
| HU (1) | HU192408B (en]) |
| IL (1) | IL72051A0 (en]) |
| PL (1) | PL248114A1 (en]) |
| PT (1) | PT78704A (en]) |
| YU (1) | YU100684A (en]) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4614738A (en) * | 1983-03-25 | 1986-09-30 | Schering Corporation | 2-(N-heterocycloaliphaticthio)penems |
| US4772597A (en) * | 1983-10-14 | 1988-09-20 | Pfizer Inc. | 2-azacycloalkylthiopenem derivatives |
| US4751299A (en) * | 1983-11-18 | 1988-06-14 | Takeda Chemical Industries, Ltd. | Optically active β-lactams and method of their production |
| GB2164334B (en) * | 1984-09-10 | 1988-08-03 | Hoechst Uk Ltd | Antibacterial 7-oxo-4-thia-1-azabicyclo 3,2,0 hept-2-ene derivativess |
| US5075439A (en) * | 1990-08-17 | 1991-12-24 | Pfizer Inc. | Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(thiocarbonyl)thio]azetidin-2-ones and intermediates therefor |
| US5288888A (en) * | 1993-04-28 | 1994-02-22 | American Cyanamid Company | Process for the synthesis of acetic acid, (dimethoxyphosphinyl) [[1,1-dimethylethyl)dimethylsilyl]-oxy]-, (4-nitrophenyl) methyl ester |
| SK13897A3 (en) * | 1996-02-06 | 1998-05-06 | Pliva Pharm & Chem Works | 3-bromo- and 3,3-dibromo-4-oxo-1-azetidines, method for preparation thereof and their use |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3668201A (en) * | 1970-02-24 | 1972-06-06 | Lilly Co Eli | Cepham compounds |
| US4020077A (en) * | 1972-07-21 | 1977-04-26 | Glaxo Laboratories Limited | Antibiotics |
| GB1476924A (en) * | 1973-08-22 | 1977-06-16 | Glaxo Lab Ltd | Preparation of d - penicillamine from penicillins |
| US4008229A (en) * | 1974-07-11 | 1977-02-15 | Eli Lilly And Company | Halo substituted β-lactam antibiotics |
| US4207323A (en) * | 1975-11-21 | 1980-06-10 | Merck & Co., Inc. | 6-Substituted methyl penicillins, derivatives and analogues thereof |
| LU77306A1 (en]) * | 1977-05-09 | 1979-01-18 | ||
| AU3796278A (en) * | 1977-07-13 | 1980-01-17 | Glaxo Group Ltd | Penams and azetidinones |
| JPS5466695A (en) * | 1977-11-08 | 1979-05-29 | Sankyo Co Ltd | Azetidinone derivative and its preparation |
| US4168314A (en) * | 1977-11-17 | 1979-09-18 | Merck & Co., Inc. | 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid |
| US4155912A (en) * | 1977-12-14 | 1979-05-22 | Bristol-Myers Company | 2-Methylpenem-3-carboxylic acid antibiotics |
| EP0042026B1 (de) * | 1978-02-02 | 1986-01-08 | Ciba-Geigy Ag | 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung |
| US4290948A (en) * | 1978-11-22 | 1981-09-22 | Beecham Group Limited | Process for their preparation of β-lactam antibacterial agents |
| US4272437A (en) * | 1978-12-18 | 1981-06-09 | Bristol-Myers Company | Antibacterial agents, and 4-thio azetidinone intermediates |
| IL59081A0 (en) * | 1979-01-10 | 1980-05-30 | Schering Corp | 2-penem compounds and a method for preparing them |
| JPS56142282A (en) * | 1980-03-10 | 1981-11-06 | Sankyo Co Ltd | Penem-3-carboxylic acid derivative and its preparation |
| ATE21105T1 (de) * | 1980-11-06 | 1986-08-15 | Hoechst Uk Ltd | 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate. |
| US4347183A (en) * | 1981-02-02 | 1982-08-31 | Schering Corporation | Process for the synthesis of penems and carbapenems |
| JPS57176988A (en) * | 1981-04-09 | 1982-10-30 | Sankyo Co Ltd | Penam-3-carboxylic acid derivative and its preparation |
| JPS57197280A (en) * | 1981-05-30 | 1982-12-03 | Sankyo Co Ltd | Preparation of 2-thioxopenam derivative |
| JPS57200392A (en) * | 1981-06-03 | 1982-12-08 | Sankyo Co Ltd | Penem-3-carboxylic acid derivative and its preparation |
| JPS57200394A (en) * | 1981-06-04 | 1982-12-08 | Yamanouchi Pharmaceut Co Ltd | Novel 2-penem compound |
| ES8305366A1 (es) * | 1981-07-08 | 1983-04-01 | Hoechst Uk Ltd | "procedimiento para la preparacion de derivados de penem". |
| AU8605382A (en) * | 1981-07-15 | 1983-01-20 | Sumitomo Chemical Company, Limited | Penicillins and azetidinones |
| DE3372773D1 (de) * | 1982-03-26 | 1987-09-03 | Hoechst Uk Ltd | 7-oxo-4-thia-1-azabicyclo(3,2,0)heptane derivatives |
-
1983
- 1983-06-10 US US06/502,894 patent/US4595539A/en not_active Expired - Lifetime
-
1984
- 1984-06-05 EP EP84303767A patent/EP0128725A1/en not_active Withdrawn
- 1984-06-06 ES ES533187A patent/ES8604600A1/es not_active Expired
- 1984-06-07 PT PT78704A patent/PT78704A/pt unknown
- 1984-06-07 IL IL72051A patent/IL72051A0/xx unknown
- 1984-06-07 GR GR74959A patent/GR82109B/el unknown
- 1984-06-08 AU AU29222/84A patent/AU544229B2/en not_active Ceased
- 1984-06-08 FI FI842329A patent/FI842329A7/fi not_active Application Discontinuation
- 1984-06-08 DK DK281884A patent/DK281884A/da not_active Application Discontinuation
- 1984-06-08 YU YU01006/84A patent/YU100684A/xx unknown
- 1984-06-08 PL PL24811484A patent/PL248114A1/xx unknown
- 1984-06-08 HU HU842220A patent/HU192408B/hu unknown
- 1984-06-09 KR KR1019840003234A patent/KR870001066B1/ko not_active Expired
- 1984-06-11 JP JP11973784A patent/JPS6140257A/ja active Pending
- 1984-06-11 JP JP59119738A patent/JPS6056954A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GR82109B (en]) | 1984-12-13 |
| KR850000448A (ko) | 1985-02-27 |
| KR870001066B1 (ko) | 1987-05-27 |
| PL248114A1 (en) | 1985-04-09 |
| YU100684A (en) | 1986-10-31 |
| HUT34201A (en) | 1985-02-28 |
| EP0128725A1 (en) | 1984-12-19 |
| PT78704A (en) | 1984-07-01 |
| DK281884A (da) | 1985-01-25 |
| AU544229B2 (en) | 1985-05-23 |
| JPS6056954A (ja) | 1985-04-02 |
| FI842329A7 (fi) | 1984-12-11 |
| US4595539A (en) | 1986-06-17 |
| IL72051A0 (en) | 1984-10-31 |
| AU2922284A (en) | 1984-12-13 |
| HU192408B (en) | 1987-06-29 |
| DK281884D0 (da) | 1984-06-08 |
| ES533187A0 (es) | 1986-02-01 |
| FI842329A0 (fi) | 1984-06-08 |
| JPS6140257A (ja) | 1986-02-26 |
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